منابع مشابه
Gramicidin and Ion Transport in Isolated Liver Mitochondria.
1. Gramicidin caused H(+) production by liver mitochondria; this process was dependent on the presence of Na(+), Li(+), Rb(+) or Cs(+). In the presence of one of these alkali-metal ions and phosphate, gramicidin caused mitochondrial swelling and increased oxygen consumption. 2. Uncoupling agents, anaerobic conditions or respiratory inhibitors both inhibited and reversed H(+) production and swel...
متن کاملIon Transport by Heart Mitochondria
The passive binding of cations to submitochondrial fragments prepared by sonic oscillation of bovine heart mitochondria has been examined. At least two different types of binding sites can be distinguished. The first site appears to be phospholipid in nature and binds the following cations in the sequence indicated: La3+ > Ca2+ > Mg2+ > K+ and Na+. Each of these cations inhibits the binding of ...
متن کاملPhosphate transport in rat-liver mitochondria.
Vesicles have been prepared by mild sonication of a purified inner membrane fraction from rat liver mitochondria. Such vesicles demonstrate an energy-dependent net concentrative uptake of inorganic phosphate in the absence of added Na+, Ca’+, or ionophores. Phosphate uptake can be supported by a variety of substrates including /?-hydroxybutyrate, succinate, and ascorbate + tetramethylphenylened...
متن کاملActive transport of potassium ion in heart mitochondria.
Several factors affecting K* transport by rabbit heart mitochondria were examined, using a K-sensitive electrode. The histone fractions f2a and j3-7 produced an energy-dependent efflux of K*. Inorganic phosphate was required for optimal activity; Km for phosphate was 60 /AM. Both rate and extent of K + efflux decreased as K concentration in the reaction medium was increased. The direction of va...
متن کاملA kinetic study of sulphate transport in rat liver mitochondria.
The kinetics of sulphate uptake catalysed by the dicarboxylate carrier were measured. The Km value for sulphate is about 0.3 mM. A completely competitive relation exists between the influxes of sulphate and malonate, whereas the relation between sulphate and phosphate is of the mixed type. The inhibition of sulphate influx by mersalyl and bathophenanthroline is similar to that of malonate influ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1968
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)93573-8